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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2AK4
All Species:
15.45
Human Site:
Y60
Identified Species:
34
UniProt:
Q9P2K8
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9P2K8
NP_001013725.2
1649
186838
Y60
P
E
I
N
L
V
L
Y
P
Q
G
L
T
G
E
Chimpanzee
Pan troglodytes
XP_001140245
1649
186793
Y60
P
E
I
N
L
V
L
Y
P
Q
G
L
T
G
E
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_535431
1633
184740
Y60
P
E
I
N
L
V
L
Y
P
Q
G
L
T
G
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9QZ05
1648
186468
Y60
P
E
I
N
L
V
L
Y
P
Q
G
L
A
G
E
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518247
1608
180821
L66
L
K
S
S
L
E
E
L
A
K
E
R
C
G
E
Chicken
Gallus gallus
XP_421203
1656
188583
P64
E
I
N
L
V
L
R
P
Q
G
L
T
G
D
D
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002667149
1483
168725
V34
A
R
E
R
C
G
E
V
M
I
Y
E
L
A
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001120977
1130
130476
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_785160
1605
181469
Q49
L
H
L
R
L
M
P
Q
Q
G
M
S
G
S
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LX30
1241
140303
Baker's Yeast
Sacchar. cerevisiae
P15442
1659
190175
T51
P
Q
I
I
F
E
I
T
L
R
S
V
D
K
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
N.A.
89.7
N.A.
90.5
N.A.
N.A.
74.7
72.3
N.A.
52.6
N.A.
N.A.
27.9
N.A.
40.4
Protein Similarity:
100
99.9
N.A.
94.3
N.A.
94.9
N.A.
N.A.
84.4
84.5
N.A.
67.4
N.A.
N.A.
44
N.A.
59.4
P-Site Identity:
100
100
N.A.
100
N.A.
93.3
N.A.
N.A.
20
0
N.A.
0
N.A.
N.A.
0
N.A.
6.6
P-Site Similarity:
100
100
N.A.
100
N.A.
93.3
N.A.
N.A.
40
20
N.A.
6.6
N.A.
N.A.
0
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.5
26.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.7
46.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
0
0
0
0
0
10
0
0
0
10
10
0
% A
% Cys:
0
0
0
0
10
0
0
0
0
0
0
0
10
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
10
10
19
% D
% Glu:
10
37
10
0
0
19
19
0
0
0
10
10
0
0
55
% E
% Phe:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
10
0
0
0
19
37
0
19
46
10
% G
% His:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
10
46
10
0
0
10
0
0
10
0
0
0
0
0
% I
% Lys:
0
10
0
0
0
0
0
0
0
10
0
0
0
10
0
% K
% Leu:
19
0
10
10
55
10
37
10
10
0
10
37
10
0
0
% L
% Met:
0
0
0
0
0
10
0
0
10
0
10
0
0
0
0
% M
% Asn:
0
0
10
37
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
46
0
0
0
0
0
10
10
37
0
0
0
0
0
0
% P
% Gln:
0
10
0
0
0
0
0
10
19
37
0
0
0
0
0
% Q
% Arg:
0
10
0
19
0
0
10
0
0
10
0
10
0
0
0
% R
% Ser:
0
0
10
10
0
0
0
0
0
0
10
10
0
10
0
% S
% Thr:
0
0
0
0
0
0
0
10
0
0
0
10
28
0
0
% T
% Val:
0
0
0
0
10
37
0
10
0
0
0
10
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
37
0
0
10
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _